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2 Pathophysiological basis: coupling of metabolic imbalance and reproductive axis 2.1 Heterogeneous phenotypes and neuroendocrine characteristics of PCOS Polycystic Ovary Syndrome is a clinically heterogeneous syndrome, and diagnosis remains syndromic: clinicians identify combinations of hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphology (PCOM), while excluding disorders with similar presentations (49)

Pratley RE, Aroda VR, Lingvay I, Ldemann J, Andreassen C, Navarria A, et al

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This highlights the ongoing need for accessible, non-invasive biomarkers that can aid in the timely detection, accurate diagnosis, and monitoring of disease progression and future treatment response