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Unlike heavy-metal pigmentation, which affects the free gingival margin, smokers melanosis develops on the attached gingiva
It acts as the ultimate electron donor for the glutaredoxin system, which activates ribonucleotide reductase (RNR) , the rate-limiting enzyme responsible for converting ribonucleotides into the deoxyribonucleotides (dNTPs) needed for DNA replication
Benoist LB, van Looij MA
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Meanwhile, PNMA undergoes self-cross-linking to form a dense polymer network, imparting excellent mechanical strength and water retention capability
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