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Alterations in growth plate development in CartIR / mice / To determine the importance of insulin signaling on growth plate development in vivo , we generated mice deficient in IR in chondrocytes as described in the section on Materials and methods
Chandys hypothesis, that the rapid onset of the repairing processes induced by B12 shots might overwhelm the system and temporarily cause a worsening in symptoms, similar to the Jarisch-Herxheimer reaction in those treated for Lyme disease
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