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Expression cloning and signaling properties of the rat glucagon receptor
The mechanism is that GLP-1 exerts its glucagon inhibitory effect in human pancreatic islets through an intrinsic (non-paracrine) PKA-dependent effect mediated by the activation of the few GLP-1Rs present in the plasma membrane of -cells, which ultimately inhibits P/Q-type Ca2+ channels (Ramracheya et al., 2018)
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Tirzepatide represents a dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that has demonstrated significant weight reduction in clinical trials
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