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Jourenkova-Mironova N et al
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Analyses were performed using various methods including inverse-variance weighting (IVW), MR Egger, weighted median, weighted mode, and simple mode
However, a follow-up study showed that protective effect of metformin treatment in APAP-associated hepatotoxicity was independent of JNK ( via inhibition of JNK, but also delays liver regeneration ( Moreover, many other signalling pathways are promoted in response to the oxidative stress in APAP overdose
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