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Overall these results confirm that FOXO4-DRI promotes apoptosis in senescent endothelial cells by inhibiting FOXO4-P53 binding and phosphorylating P53

7 Prospects in gut microbiota-mediated cardiovascular disease The integration of advanced technologies, such as CRISPR/Cas9, enables precise modulation of gut microbiota metabolic pathways, thereby enhancing the targeted expression of cardioprotective metabolites

No pharmacokinetic or pharmacodynamic interaction studies exist for the combination

Only Epitalon, a peptide that has been employed to alleviate insomnia, was rejected by the panel