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These drugs (including Wegovy, Mounjaro, Zepbound, and others) are glucagon-like peptide-1 receptor agonists (GLP-1 RAs or GLP-1s)
Wegovy is generally more effective, potentially leading to a 15.85% body weight reduction over time compared to Saxenda's 6.4%
A SURMOUNT post-hoc analysis of 2,542 women found perimenopausal women on tirzepatide lost 23% of body weight vs 3% on placebo, nearly identical to the 26% loss in premenopausal women
Weight regain is not a failure of willpower
10.1016/j.cmet.2017.04.013 27 GreinerT
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