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[5] Boxed safety statements highlight additional populations for whom estradiol therapy must be avoided, including pregnant individuals, women with active systemic lupus erythematosus experiencing vascular flares, and patients with protein C, protein S, or antithrombin deficiencies that potentiate thrombosis

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Several classes of GST have been shown to exhibit non-catalytic ligand binding in the dimer interface 13,15

early referral prevents disease progression and may improve medical outcomes