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Chromatin-modifying agents in anti-cancer therapy

This cumulative effect results in a consistent therapeutic level after about 4-5 half-life cycles

Diabetologia 54(11):27452754 Malavazos AE, Meregalli C, Sorrentino F, Vignati A, Dubini C, Scravaglieri V, Basilico S, Boniardi F, Spagnolo P, Malagoli P, Romanelli P, Secchi F, Iacobellis G (2023) Semaglutide therapy decreases epicardial fat inflammation and improves psoriasis severity in patients affected by abdominal obesity and type-2 diabetes

This provides a dual mechanism: enhanced immune regulation through Tregs plus direct cytokine suppression

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