In clinical trials, people taking these medications lost 10-15% of their body weight on average
If you maintain the positive changes in diet, exercise, and overall wellness that contributed to your weight loss, its possible to keep the weight off after stopping the medication
Incretins and their synthetic mimetics offer benefits by influencing the appetite and satiety centers in the brain, potentially resetting the bodys fat mass and body weight setpoints that are associated with the interplay between orexigenic and anorexigenic signaling pathways
It seems that weight loss will likely be very important for the benefits of the GLP-1 medicines in some conditions, and much less important, or not at all essential, for benefits in other disorders. According to Lane, although GLP-1 receptor agonists show promise in reducing cardiovascular risk factors, long-term cardiovascular safety trials are needed to assess cardiovascular mortality and events
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