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Semaglutide 2.4 mg (Wegovy): ~15% body weight loss at 68 weeks in clinical trials Tirzepatide 15 mg (Zepbound): ~21% body weight loss at 72 weeks in clinical trials Real-world data shows lower results: Cleveland Clinic research from 2025 found average weight loss of 7.7% with semaglutide and 12.4% with tirzepatide at one year in routine clinical practice

Individuals with insulin resistance or prediabetes

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Healthcare providers recommend limiting: Caffeinated drinks and alcohol with Ozempic Full-fat dairy products Greasy or fried foods Foods high in added sugars Regular blood sugar monitoring helps prevent complications, as Ozempic can affect glucose levels