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10.1016/S0891-5849(97)00165-2 313 ZhangW

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The liability exposure for prescribing unapproved peptides centers on adequate informed consent and documentation demonstrating the prescription serves a legitimate therapeutic purpose not achievable through FDA-approved alternatives

The practical result can include temporary increased fine lines, mild sagging, or a "tired" appearance

The intertwined roles of PERK and IRE1 in angiogenesis, EMT, dormancy, and therapy resistance emphasize why indiscriminate UPR inhibition is unlikely to succeed clinically and why pathway-selective, context-aware strategies are needed