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By contrast, metformin appears to exert broader effects on pathways directly implicated in AD pathogenesis, including AMPK, insulin, and adipocytokine signaling

Patients sometimes assume that a more complex mechanism automatically means a medicine is better

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When evaluating a therapy or supplement, consider the following: Look for Human Clinical Trials Animal or mechanistic studies can be promising, but randomized controlled human trials provide stronger evidence of real-world effectiveness

Its pathway to NHS availability will depend on the successful completion of Phase 3 TRIUMPH trials, followed by a marketing authorisation application to the MHRA (the UK's independent medicines regulator) and potentially the EMA for European markets