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Suggested conservative titration: Start at 200250 mcg daily

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Women who were already receiving hormone therapy may have differed from those who were not in ways that the matching process did not fully capture: differences in baseline metabolic health, in how long they had been postmenopausal, in their physical activity levels, or in other clinical factors that influence GLP-1 responsiveness

Reduced estrogen levels during perimenopause and menopause can affect appetite regulation and metabolism, making weight management harder than it used to be

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