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Measurements included hydrodynamic diameter (2RH), polydispersity index (PDI) and zeta potential (ZP) (Table 1), which were obtained using dynamic light scattering (DLS) with a NanoBrook Omni analyzer (Brookhaven Instruments Corporation, Holtsville, NY, USA)

Importantly, they also illustrate how defects at distinct levels of the UPS, substrate recognition, ubiquitin recycling or proteasome targeting, can converge on a common outcome of proteotoxic stress and neurodegeneration

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GHK-Cu (Copper Tripeptide) is a copper-binding peptide complex formed by the tripeptide glycyl-L-histidyl-L-lysine (GHK) coordinated with a divalent copper ion