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Adverse ocular effects associated with niacin therapy
However, they appear to produce similar results to injectables
In populations with added comorbidities, results are lower: TRIUMPH-2 (obesity + diabetes) showed 20.8%, TRIUMPH-3 (obesity + cardiovascular disease) showed 22.6%, and TRANSCEND-T2D-1 (diabetes-specific, 40 weeks) showed 16.8% all consistent with patterns seen across the GLP-1 drug class, where comorbidities reduce achievable weight loss
This represents substantial weight loss that exceeds most other approved weight management medications
This system could be stimulated in the first minutes before a meal and would be involved in foraging and the cephalic phase of insulin secretion, as we have recently shown 16
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