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Semaglutide enhanced METTL3/14 and insulin signaling gene expressions in pancreatic of obese mice similar to calorie restriction To elucidate the mechanism of semaglutide improving islet function in obese mice whether the same as calorie restriction, METTL3/14 (m6A genes), PDX1(transcription factors critical for beta cell development and maturation), the insulin signaling pathway (AKT-1, INSR, IRS-2, IGF1R) were investigated in the pancreatic tissues

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