This is firmly in the territory of working closely with a clinician and following a structured protocol
The focus on GLP-1 alone has proven effective, but it also means that some patients may not experience the same level of metabolic improvement as those using Mounjaro
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Firstly, through a systematic review and network meta-analysis, researchers have assessed the effects of GLP-1R agonists on neuroinflammation and reported that, compared with placebo, GLP-1R agonists significantly reduce the levels of neuroinflammatory markers, such as TNF- and interleukin-1 (Urkon et al., 2025
The researchers point out that GLP-1RAs are expensive and can potentially widen health disparities as obesity disproportionately affects marginalized racial, ethnic and socioeconomic communities