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This axis regulates the gut microbiota and brain function bidirectionally through neural anatomical pathways, neuroimmune and neuroendocrine routes, the intestinal mucosal barrier, microbial metabolites, and the blood-brain barrier

This inherent protective quality is not confined to a single organ system but rather exerts a stabilizing influence across various tissues, providing the mechanistic foundation for its dual action in both the gastrointestinal tract and the central nervous system

Its safety and effectiveness for human use have not been confirmed through comprehensive clinical trials

A single overnight temperature excursion (812 hours at 2025C) typically causes 815% degradation depending on ambient temperature and light exposure

doi: 10.1186/1471-2172-13-2 52 BakheetSAAnsariMANadeemAAttiaSMAlhoshaniARGulGet al