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It does not extend to outpatient procedures such as B12 injections unless you are hospitalized and the injection is part of your treatment plan during your stay

A 2025 Journal of Allergy and Clinical Immunology report (n=500) noted mild erythema in 8% of cases, subsiding within 24-48 hours without intervention

This makes it relevant for forehead lines, crow feet, and other expression-related wrinkles

Side effects [edit] The literature data on the acute toxicity profile of hydroxocobalamin show it is generally regarded as safe with local and systemic exposure