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In both patient populations with pre-existing cardiovascular disease, DPP-4 inhibitors are recommended as one possible third-line therapy besides SGLT-2 inhibitors, thiazolidinediones, or insulin, when therapeutic goals are not met with the previous dual combination
When to contact your prescriber Most GI side effects are uncomfortable but not dangerous
The fatigue during early semaglutide use more likely results from caloric restriction, changes in eating patterns, and the medication adjusting appetite and satiety signals
10.1016/j.ibmb.2007.02.001 227 WhittenM
Long, M
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