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Pharmacological inhibition of GLS via CB-839 or BPTES amplifies PCa cell sensitivity to metformin ( 4.3.7 Limitations of drugs targeting ammonium metabolism Although systematic investigations into the adverse effects of ammonium metabolism-targeting agents in prostate cancer remain limited, their toxicological profiles have been relatively well characterized in other solid tumors, such as breast, pancreatic, and gastrointestinal cancers (211, 222, 238)