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The targets of area postrema neuronal projections include the rostral ventrolateral medulla (RVLM), with the efferent projections from the RVLM innervating the sympathetic preganglionic neurons (183)

Regarding receptor-specific interactions, the retatrutideGLP-1R complex displays three salt bridges (D9 P R 7.35b , D15 P R299 ECL2 and K17 P E 1.33b ), with the first two also present in the retatrutideGIPR complex, while the last one is absent in GIPR due to the positively charged R131 1.33b