stopping and restarting semaglutide What to Do When Stops Working to Restart Progress If a patient stops tirzepatide

The UK SmPC for Wegovy includes a warning about these findings but does not list a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) as formal contraindications, unlike in some other jurisdictions

In most reported cases, discontinuation of the CGRP antagonist resulted in resolution of symptoms

However, some individuals may experience: Injection site reactions such as mild redness, itching, or swelling Water retention or mild fluid buildup, particularly in the early weeks Joint discomfort or stiffness, which often resolves as the body adjusts Tingling or numbness in the hands or feet (less common) Elevated blood glucose levels in individuals predisposed to insulin resistance It is worth noting that tesamorelin should not be used by individuals with active cancer, those who are pregnant, or patients with hypersensitivity to its components

Results are anticipated at the end of 2025 and into 2026

Animal studies spanning over a decade confirm significant improvements in esophagitis, sphincter function, and overall digestive health with both injectable and oral administration