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The renal thiol (glutathione) oxidase
Podocytes also present an insulin-dependent alternative pathway, the cyclic guanosine monophosphate(cGMP)-dependent protein kinase G (PKG), from which the PKG isoform I-alpha levels are increased in glomeruli of the hyperinsulinemic Zucker rats ( An important player in podocytes physiology is the protein nephrin, a podocyte-specific protein, which is responsible for the maintenance of the integrity of the filtration barrier
doi.org/10.1093/humupd/dmt037 Wang T, Babayev E, Jiang Z, et al
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Immunofluorescence analysis of SREBP2 expression in Huh-7 cells showed that compared with the CON group, the ALC group had significantly reduced SREBP2 levels, and similarly, compared with the TG group, the ALC + TG group had significantly reduced SREBP2 levels (Figures 6F,G)
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