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Practical Implications of No IGF-1 Elevation: The absence of IGF-1 stimulation makes AOD-9604 suitable for populations who need to avoid IGF-1 elevation, including individuals with personal or family history of hormone-sensitive cancers, those concerned about accelerated aging through growth pathway activation, people seeking fat loss without anabolic muscle-building effects, individuals who have contraindications to growth hormone therapy, and those undergoing screening or monitoring where IGF-1 elevation would be problematic

This is suggested by in vitro work by Ng et al

Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy [7]

Key finding: AOD 9604 reduced serum leptin by 56%, improved hypothalamic STAT3 phosphorylation, and restored leptin-induced POMC expression

A small amount (approximately 1% of the total amount ingested) is absorbed by simple diffusion, but this mechanism is adequate only with very large doses