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[2] The head-to-head ACHIEVE-3 trial, published in The Lancet in February 2026, compared orforglipron 36 mg to oral semaglutide 14 mg in 1,698 patients with type 2 diabetes over 52 weeks
Vigorous exercise should be avoided during the first four weeks
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See our semaglutide guide
However, if you take diabetes medications like insulin or sulfonylureas, timing becomes medically importantdiscuss your full medication list with your PlexusDx care team to prevent low blood sugar
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