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The liver is the principal site for the hydroxylation of cholecalciferol at carbon 25 by 25-hydroxylase enzymes (CYP2R1 and CYP27A1) to form 25(OH)VD 3

Insulin resistance itself impairs hair follicle function through multiple pathways: reduced IGF-1 signaling, chronic inflammation, and microvascular dysfunction

This perspective contrasts with failed targets , for which rigorous clinical evaluation has demonstrated unacceptable on-target toxicity or lack of efficacy at therapeutically relevant exposures