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Among the candidate genes associated with the characteristic phenotype of individuals with T21, DYRK1A, located on DSCR1, has emerged as the most promising target

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TRAIL-Rs TNF-related apoptosis-inducing ligand receptors (TRAIL-Rs), belonging to the TNF receptor superfamily, play a pivotal role in immune regulation by interacting with the TRAIL to mediate apoptosis in MDSCs [113]