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Inhibition of endocytosis with dynasore blocked both VEGFR2 internalization and the pro-angiogenic effects of BPC 157, confirming the essential role of this process
The report was uncontrolled, unblinded, not randomized, had no comparator arm, used patient-reported outcomes rather than validated pain instruments, and did not publish dose, effect size, confidence intervals, p-values, or systematically collected adverse events limitations that severely constrain any clinical inference
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