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REDEFINE 1 and REDEFINE 2 Late-Breaking Symposium
Free fatty acids from either adipose tissue (fat), or from the conversion of excess carbohydrate intake, accumulate in the liver cell resulting in oxidative stress, inflammation, and liver injury
Three 20-week double-blind, placebo-controlled studies each with 34-week extensions were conducted to evaluate the efficacy and safety of sitagliptin in 410 pediatric patients aged 10 to 17 years with inadequately controlled type 2 diabetes, with or without insulin therapy (HbA1c 6.5-10% for patients not on insulin, HbA1c 7-10% for patients on insulin)
These behaviors, while not always meeting full diagnostic criteria, are consistently associated with disturbances in impulse control [10], alterations in reward processing [11, 12] and stress-related eating mechanisms [13]
Because retatrutide is potent and multi-acting, it will likely require stricter screening and monitoring than older medications
