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Evidence boundary The largest Phase 2b trial used oral dosing for 24 weeks and did not show statistically significant weight loss versus placebo
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People Taking Certain Medications Long-term use of metformin (a common diabetes medication) and proton pump inhibitors (PPIs) like omeprazole can reduce B12 absorption over time
Green et al 26 Severe clinical abnormalities should be treated intensively with B 12 , cyanoB 12 or hydroxyB 12 : HydroxyB 12 is commonly used in Europe, often at intervals of 23 months, as it seems to have better retention than cyanoB 12
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