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PHD activates the pseudohypoxic response by stabilizing HIF-1, which is a well-known tumorigenesis enhancer, and as a transcription factor, maintains the metabolic reprogramming of cancer cells to support their survival 127

FACS analysis confirmed that at passage 10, 54.7% of EpCAM+ HBs co-expressed the proliferative marker Ki67, and immunostaining showed sustained co-expression of AFP, HNF4, and Ki67

14 GST is widespread in tumor cells, and is intricately involved with cellular carcinogenesis, tumor formation, and tumor-drug resistance

Food, environment, lifestyle and gut function may all influence gene expression, inflammation, mitochondrial function and methylation without changing the DNA sequence

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