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The dermoscopic patterns of melanoma in this setting of patients were not evaluated in the studies

When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before

Also appropriate if the constipation is significantly affecting quality of life or causing secondary symptoms like hemorrhoids or anal fissure from straining

Moreover, Tanshinone IIA (Tan IIA), a natural compound from Salvia miltiorrhiza, has been found to have anti-fibrotic effects