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When BPC-157 was co-administered with diazepam over 10 days (a protocol that normally produces robust tolerance), tolerance development was prevented and physical dependence was postponed

Remarkably, malic enzyme 1 (ME1), which yields pyruvate from malate and converts NADP + to reduced nicotinamide adenine dinucleotide phosphate (NADPH), might reduce the accumulation of ROS and redox-active iron, hence resisting ferroptosis induced by inhibition of SLC7A11 [43]