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Combinations with codeine, tramadol, or other opioid medicines carry additional risks including dependence, sedation, constipation, respiratory depression, and driving impairment

Peptides are chains of amino acids and the digestive system breaks those chains apart, so how much intact peptide reaches circulation orally is not well established

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41 Healthcare disparities exist, as Black and Hispanic patients are significantly less likely to be prescribed GLP-1RA compared to White and non-Hispanic patients

Yet, when standardized for body weight variations, the BMC to body weight ratio appeared consistent