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doi: 10.1210/clinem/dgab722 58 ForzanoIVarzidehFAvvisatoRJankauskasSSMonePSantulliG
The GSH/GPX4 node is the crucial regulator of ferroptosis The GSH system, as a lipid peroxide scavenger, has attracted much attention as a potential therapeutic target for ferroptosis
Second, cancer cells are highly adaptable and can activate compensatory antioxidant pathways, like the thioredoxin system, to survive GSH inhibition, reducing therapeutic effectiveness
These are the same pathways cancer cells exploit to grow and spread
A 0.4 mL/min linear gradient elution was used: 01 min, 9075% solvent B, 12 min, 7565% solvent B, 24 min, 6555% solvent B, 45 min, 5540% solvent B
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