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Regarding eGFR trajectories, both drugs induced a slightly slower decline in eGFR compared to the placebo groups, which was more pronounced in people with moderate (eGFR 3059 mL/min/1.73 m 2 ) or severe (eGFR 50%, reaching ESKD, death from kidney disease or death from CVD

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Additionally, melatonin may modulate the hyperphosphorylation of the microtubule-associated tau protein, a process leading to the formation of NFTs characteristic of AD [32]

Methods We searched PubMed, Embase, and Cochrane for randomized controlled trials published from inception to July 2022, comparing tirzepatide with placebo for the co-primary endpoints of absolute and percent change in weight