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The platypus GLP-1R amino acid sequence (deduced in this study from a sequenced cDNA transcript) is similar to the hGLP-1R (76% identity compared to hGLP-1R), including conservation of the residues important for ligand binding (Fig

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In the STEP trials, semaglutide 2.4mg weekly resulted in mean weight reductions of 1517% over 68 weeks, whilst tirzepatide in the SURPASS trials showed reductions of 1520% (Kushner et al

Nevertheless, PBM sources and marketplace analyses provide a window into typical GLP-1 access policies