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Microdosing involves using doses below manufacturer-recommended levels without supporting clinical trial data on efficacy or safety
The pathophysiology of DOX-induced POI is complex, but numerous factors have been proposed to be linked to the onset and development of ovarian dysfunction, including free radical-mediated lipid peroxidation, oxidative stress, mitochondrial malfunction, increased proinflammatory release of cytokines, and granulosa cell apoptosis 12,13,14
Meanwhile, in human ecstasy abusers, there are evidences for deficits in seronergic biochemical markers, which correlate with long-term impairments in memory and learning
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