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While our findings with ErbB2+ GEMMs validated the effects of FAO inhibition using etomoxir, a known CPT1-specific inhibitor, concerns about off-target effects at higher doses call for the development of more specific and effective Cpt1a inhibitors (Fig

Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, et al

They have a direct effect on egg quality, sperm quality and embryo viability

Fundamentals of redox regulation in biology

After absorption, the first step of the reductive assimilation of sulfate is its adenylation to adenosine 5-phosphosulfate (APS), a reaction catalyzed by ATP sulfurylases (ATPS) (Figure 1