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Inhibiting MAO-B activity in cocaine-naive mice, with pargyline or deprenyl pretreatment, reduces cocaine self-administration compared to saline or the MAO-A inhibitor, clorgyline [119]

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Theoretical concerns exist for individuals with active cancer due to angiogenic properties, though research hasn't identified increased cancer risk

The inhibition of serine and glycine bidirectional conversion by sertraline prior irradiation reduces the pool of nucleotides, as we previously observed, and concurrent and post-treatment with sertraline might hinder the synthesis of the antioxidant GSH and NADPH production, which exposes cancer cells to the accumulation of endogenous ROS and radiation-induced ROS causing severe oxidative stress [70]