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A tricky thing with semaglutide is that GI symptoms (such as nausea, vomiting, and diarrhea) are the most common side effectsand each one can dehydrate you, indirectly contributing to fatigue
However, preclinical safety studies report no major toxicity across animal studies (mice, rats, rabbits, dogs) and showed no adverse effects across several organ systems
Back Mojsov, S, Weir, GC, Habener, JF (Feb 1987) 'Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas', Journal of Clinical Investigation , 79, 616-19
The same medications can also create practical side-effect questions
injection with 100 nmol kg 1 MK-801 ( n = 7 mice), 100 nmol kg 1 GLP-1 ( n = 8 mice), 100 nmol kg 1 GLP-1MK-801 ( n = 7 mice) or vehicle (isotonic saline, n = 8 mice) in lean mice
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