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The guiding principle from clinical data is clear: escalate every four weeks, starting from the lowest effective dose, and never increase if side effects from the current dose have not stabilized

Seek urgent help if you experience these symptoms and discuss whether to continue treatment with your prescriber

Specifically, a study of zibotentan, a highly selective endothelin A ERA, in combination with dapagliflozin in participants with type 2 diabetes (NCT05570305) is currently underway, with similar phase 2 trials in type 1 diabetes being proposed

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