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Results clearly showed that the tyrosine-nitration level was reduced in proportion to the molar ratios of GSSSG and LASSS relative to HGF, as revealed by the decrease in anti-nitroY mAb-positive HGF (60-kDa -chain and 90-kDa proform) normalized to total HGF -chain as a loading control, that was monitored by stripping with SDS-ME solution and re-probing the blot with anti-HGF -chain N-terminal domain mAb (Figure 1b,c, second and third rows)
The various treatments for MASHlifestyle modifications, glucagon-like peptide (GLP) 1 receptor agonists, GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) dual agonists, resmetirom, metabolic-bariatric surgery, and metabolic-bariatric endoscopic proceduresreduce steatosis by distinct but converging pathways (Figure 1)
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10.3389/fphar.2022.855779 33 IshikawaM.TakasekiS.YoshitomiT.CoveyD
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