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doi: 10.3390/nu13020303

The success of such an undertaking depends, however, on a few particular, both practical and theoretical, considerations

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Preclinical studies demonstrate that DSIP can alter pain threshold responses, with observed effects that are not reversed by opioid receptor antagonists such as naloxone, suggesting involvement of non-opioid or indirect neuromodulatory pathways [7]

There is no robust clinical evidence that vitamin B12 pills cause weight loss in people who are not deficient, and neither NICE nor the NHS recommends B12 supplementation as a weight management strategy