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doi: 10.1016/j.fshw.2021.02.026 117

In research settings, it is examined as an isolated pentadecapeptide with consistent physicochemical characteristics, which supports its use across biochemical, cellular, and preclinical experimental platforms

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In turn, Per and Cry dimerize, acting as the negative limb of the feedback loop to inhibit Clock:Bmal1 transcriptional activity for the cycle to repeat, and degradation of Per and Cry proteins are responsible for terminating repression and restarting transcription