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The GLP-1 receptor agonists (semaglutide, liraglutide, dulaglutide) and the GIP/GLP-1 dual agonist tirzepatide sit behind the STEP (NEJM, 2021), SURMOUNT (NEJM, 2022), and SURMOUNT-OSA (NEJM, 2024) evidence, and the clinical picture does not change with the price tag

By restoring those levels, many men notice improved energy, improved mental cognition, happier mood, better recovery, increased muscle, and a more favorable body composition over time, he explained

GLP-1 agonists have been shown to improve insulin secretion, decrease glucagon production, increase satiety, and help decrease food intake

Have more energy and I'm not craving food all the time!" Alisa H

A separate 2024 meta-analysis in the journal Endocrine examining 29 trials with 26,985 participants with type 2 diabetes confirmed that semaglutide significantly reduced systolic blood pressure by about 2.31 mmHg compared to placebo or other antihyperglycemic agents