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Randomization was 1:1 to semaglutide or placebo, stratified by sex, using block sizes of six via an online randomization system

This disparity is hypothesized to arise from differences in estrogen-mediated neuroprotection, lifestyle factors, and occupational exposure to neurotoxins (Ben-Shlomo et al., 2024) (Figure 2)

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MOTS-c : Strong mitochondrial peptide for metabolism, exercise performance, energy, and insulin sensitivity

that is, fasting glucose 5% of initial body weight) was explained by improved insulin sensitivity and reduced visceral adipose tissue (VAT) volume