The role of PDE3B phosphorylation in the inhibition of lipolysis by insulin
The SURMOUNT-1 trial enrolled 2,539 patients with obesity, excluding individuals with diabetes or uncontrolled hypertension, and randomized them to placebo or 5, 10, or 15 mg of tirzepatide
The combined primary endpoint of death from cardiovascular disease, nonfatal myocardial infarction, or nonfatal stroke occurred in 569 (6.5%) of patients in the semaglutide group versus 701 (8.0%) of patients in the placebo group, yielding a significant hazard ratio of 0.8 for a 20% relative risk reduction
CLA supports body composition but may take longer to show visible results
GLP-1 related hair loss is predominantly telogen effluvium, which is a temporary and self-resolving condition